HCID 14901692, compound → HCID 58863431, compound

HRID 1159561Notes

Reaction equation

HRID 1159561 reaction equation
C([N:3]([CH2:14][CH3:15])[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:6]=1[CH3:12])C.[OH:16][C@@H:17]1[CH2:21][CH2:20][N:19]([CH2:22]CC(N(OC)C)=O)[CH2:18]1>>[Cl:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]2[C:6]=1[CH:12]=[C:14]([CH2:15][CH2:22][N:19]1[CH2:20][CH2:21][C@@H:17]([OH:16])[CH2:18]1)[NH:3][C:4]2=[O:13]

Participants

3

Reactant 2

HCID 14901692HCID 14901692, compoundHCID 58863437HCID 58863437, compound

Product 1

HCID 58863431HCID 58863431, compoundYield 2.3%

Procedure

In the same manner as in Example 16b and using N,N-diethyl-3-chloro-2-methylbenzamide (3.43 g) and (R)-3-(3-hydroxypyrrolidin-1-yl)-N-methoxy-N-methylpropanamide (3.08 g), (R)-5-chloro-3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-2H-isoquinolin-1-one (102 mg) was obtained.

Sources & evidence

ORD record
ord-e02881d65bda48b3a45b2d269cb61637
Source dataset
uspto-grants-2010_10
Patent number
US07812178B2

Reaction notes

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