HCID 14901692, compound → HCID 68644236, compound

HRID 1159563Notes

Reaction equation

HRID 1159563 reaction equation
[CH3:1][O:2][CH2:3][C@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[CH2:9]CC(N(OC)C)=O.C([N:19]([CH2:30][CH3:31])[C:20](=[O:29])[C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:22]=1[CH3:28])C>>[ClH:27].[Cl:27][C:23]1[CH:24]=[CH:25][CH:26]=[C:21]2[C:22]=1[CH:28]=[C:30]([CH2:31][CH2:9][N:5]1[CH2:6][CH2:7][CH2:8][C@@H:4]1[CH2:3][O:2][CH3:1])[NH:19][C:20]2=[O:29]

Participants

3

Reactant 2

HCID 14901692HCID 14901692, compoundHCID 86613522HCID 86613522, compound

Product 1

HCID 68644236HCID 68644236, compoundYield 43.4%

Procedure

In the same manner as in Example 20b and using (R)-3-(2-methoxymethylpyrrolidin-1-yl)-N-methoxy-N-methylpropanamide (3.2 g) and N,N-diethyl-3-chloro-2-methylbenzamide (3.2 g), (R)-5-chloro-3-[2-(2-methoxymethylpyrrolidin-1-yl)ethyl]-2H-isoquinolin-1-one hydrochloride (1.1 g) was obtained.

Sources & evidence

ORD record
ord-122a9f9bc85d407fae19f7afad68d350
Source dataset
uspto-grants-2010_10
Patent number
US07812178B2

Reaction notes

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