HCID 14901692, compound → HCID 68644253, compound

HRID 1159565Notes

Reaction equation

HRID 1159565 reaction equation
[CH2:1]([O:3][CH2:4][C@H:5]1[CH2:9][CH2:8][CH2:7][N:6]1[CH2:10]CC(N(OC)C)=O)[CH3:2].C([N:20]([CH2:31][CH3:32])[C:21](=[O:30])[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[C:23]=1[CH3:29])C>>[ClH:28].[Cl:28][C:24]1[CH:25]=[CH:26][CH:27]=[C:22]2[C:23]=1[CH:29]=[C:31]([CH2:32][CH2:10][N:6]1[CH2:7][CH2:8][CH2:9][C@@H:5]1[CH2:4][O:3][CH2:1][CH3:2])[NH:20][C:21]2=[O:30]

Participants

3

Reactant 2

HCID 14901692HCID 14901692, compoundHCID 86613523HCID 86613523, compound

Product 1

HCID 68644253HCID 68644253, compoundYield 55.9%

Procedure

In the same manner as in Example 20b (b) and (c) and using (R)-3-(2-ethoxymethylpyrrolidin-1-yl)-N-methoxy-N-methylpropanamide (1.22 g) and N,N-diethyl-3-chloro-2-methylbenzamide (1.13 g), (R)-5-chloro-3-[2-(2-ethoxymethylpyrrolidin-1-yl)ethyl]-2H-isoquinolin-1-one hydrochloride (0.52 g) was obtained.

Sources & evidence

ORD record
ord-a6c8f4d0200a4d17be5995f9e5d6d55b
Source dataset
uspto-grants-2010_10
Patent number
US07812178B2

Reaction notes

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