2,2-Dimethyl-3,4-epoxy-6-cyanochroman → HCID 178431196, compound

HRID 1159615Notes

Reaction equation

HRID 1159615 reaction equation
[CH3:1][C:2]1([CH3:15])[O:11][C:10]2[C:5](=[CH:6][C:7]([C:12]#[N:13])=[CH:8][CH:9]=2)[CH:4]2[O:14][CH:3]12.[F:16][CH:17]([F:29])[O:18][C:19]1[CH:28]=[CH:27][C:22]2[NH:23][C:24]([SH:26])=[N:25][C:21]=2[CH:20]=1>>[F:29][CH:17]([F:16])[O:18][C:19]1[CH:28]=[CH:27][C:22]2[NH:23][C:24]([S:26][CH:4]3[C:5]4[C:10](=[CH:9][CH:8]=[C:7]([C:12]#[N:13])[CH:6]=4)[O:11][C:2]([CH3:15])([CH3:1])[CH:3]3[OH:14])=[N:25][C:21]=2[CH:20]=1

Participants

3

Reactant 2

HCID 108673602,2-Dimethyl-3,4-epoxy-6-cyanochromanHCID 178506406HCID 178506406, compound

Product 1

HCID 178431196HCID 178431196, compound

Procedure

Following the procedure in Example 1, using (±)-2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalene-6-carbonitrile and 5-difluoromethoxy-1H-benzoimidazole-2-thiol as starting material, the title compound was prepared as a white solid.

Sources & evidence

ORD record
ord-8eb7cae1f118400495c9e98d01019536
Source dataset
uspto-grants-2010_10
Patent number
US07812183B2

Reaction notes

Loading…