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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1159618Generated: October 27, 2026

1,2-Benzisothiazol-3(2H)-one → 4-(Benzo[d]isothiazol-3-yloxy)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

https://huagongshe.com/reaction/1159618

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2-Benzisothiazol-3(2H)-oneHCID 17520—
Reactant2,2-Dimethyl-3,4-epoxy-6-cyanochromanHCID 10867360—
Product4-(Benzo[d]isothiazol-3-yloxy)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrileHCID 66700020—

Reaction Steps

Following the procedure in Example 1, using (±)-2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalene-6-carbonitrile and benzo[d]isothiazol-3-one as starting material, the title compound was prepared as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07812183B2
Source datasetuspto-grants-2010_10
ORD IDord-1b492fdf74994c839099ebccf0808b9e
Source noteuspto-grants-2010_10