5-chlorobenzo[d]isoxazol-3-ol → HCID 68644261, compound

HRID 1159622Notes

Reaction equation

HRID 1159622 reaction equation
[CH3:1][C:2]1([CH3:15])[O:11][C:10]2[C:5](=[CH:6][C:7]([C:12]#[N:13])=[CH:8][CH:9]=2)[C@@H:4]2[O:14][C@H:3]12.[Cl:16][C:17]1[CH:18]=[CH:19][C:20]2[O:24][NH:23][C:22](=[O:25])[C:21]=2[CH:26]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]2[O:24][N:23]=[C:22]([O:25][C@@H:4]3[C:5]4[C:10](=[CH:9][CH:8]=[C:7]([C:12]#[N:13])[CH:6]=4)[O:11][C:2]([CH3:1])([CH3:15])[C@H:3]3[OH:14])[C:21]=2[CH:26]=1

Participants

3

Reactant 2

HCID 37141695-chlorobenzo[d]isoxazol-3-olHCID 9837089(1aS,7bS)-2,2-Dimethyl-1a,7b-dihydro-2H-oxireno[2,3-c]chromene-6-carbonitrile

Product 1

HCID 68644261HCID 68644261, compound

Procedure

Following the procedure in Example 1, using (S,S)-2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalene-6-carbonitrile and 5-chloro-benzo[d]isoxazol-3-one (prepared by literature known method) as starting materials, the title compound was prepared as a white solid.

Sources & evidence

ORD record
ord-fc81d46c0b5041aeb9a43298933f3f78
Source dataset
uspto-grants-2010_10
Patent number
US07812183B2

Reaction notes

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