2,2-Dimethyl-3,4-epoxy-6-cyanochroman → HCID 178426373, compound

HRID 1159627Notes

Reaction equation

HRID 1159627 reaction equation
[CH3:1][C:2]1([CH3:15])[O:11][C:10]2[C:5](=[CH:6][C:7]([C:12]#[N:13])=[CH:8][CH:9]=2)[CH:4]2O[CH:3]12.[NH2:16][C:17]1[NH:18][C:19]2[C:24]([C:25](=[O:27])[N:26]=1)=[CH:23][CH:22]=[CH:21][CH:20]=2>>[CH3:1][C:2]1([CH3:15])[CH:3]=[C:4]([NH:16][C:17]2[NH:18][C:19]3[C:24]([C:25](=[O:27])[N:26]=2)=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:5]2[C:10](=[CH:9][CH:8]=[C:7]([C:12]#[N:13])[CH:6]=2)[O:11]1

Participants

3

Reactant 2

HCID 108673602,2-Dimethyl-3,4-epoxy-6-cyanochromanHCID 178508850HCID 178508850, compound

Product 1

HCID 178426373HCID 178426373, compound

Procedure

Following the procedure in Example 1, using 2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalene-6-carbonitrile and 2-amino-1H-quinazolin-4-one as starting materials, the title compounds were prepared as white solids.

Sources & evidence

ORD record
ord-59dc9053b5824c10b730c1ff58825aaa
Source dataset
uspto-grants-2010_10
Patent number
US07812183B2

Reaction notes

Loading…