HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophthalic anhydride → 4-(5-Chloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophthalic anhydride | HCID 67044 | — |
| Reactant | (3S,4R)-4-amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile | HCID 10943936 | — |
| Product | 4-(5-Chloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile | HCID 66700058 | — |
Reaction Steps
Following the procedure in Example 89, using (3S,4R)-4-amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile and 5-chloro-isobenzofuran-1,3-dione as starting materials, the title compound was prepared as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812183B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-e424b0c9b4784373bb8e96bf493329e0 |
| Source note | uspto-grants-2010_10 |