3-Chlorobenzenesulphonyl chloride → HCID 44564185, compound

HRID 1159638Notes

Reaction equation

HRID 1159638 reaction equation
[NH2:1][C@@H:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]#[N:13])[CH:10]=2)[O:5][C:4]([CH3:15])([CH3:14])[C@H:3]1[OH:16].[Cl:17][C:18]1[CH:19]=[C:20]([S:24](Cl)(=[O:26])=[O:25])[CH:21]=[CH:22][CH:23]=1>>[Cl:17][C:18]1[CH:19]=[C:20]([S:24]([NH:1][C@@H:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([C:12]#[N:13])[CH:10]=3)[O:5][C:4]([CH3:14])([CH3:15])[C@H:3]2[OH:16])(=[O:26])=[O:25])[CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 179093-Chlorobenzenesulphonyl chlorideHCID 10943936(3S,4R)-4-amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

Product 1

HCID 44564185HCID 44564185, compound

Procedure

Following the procedure in Example 105, using (3S,4R)-4-amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile and 3-chloro-benzenesulfonyl chloride as starting materials, the title compound was prepared as a pale yellow solid.

Sources & evidence

ORD record
ord-f26e70c3435d4314839503888de54472
Source dataset
uspto-grants-2010_10
Patent number
US07812183B2

Reaction notes

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