HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Lutidine → 1-[(4-Fluorophenyl)sulfonyl]-1H-indole-4-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Lutidine | HCID 7937 | — |
| Reactant | Sodium periodate | HCID 23667635 | — |
| Reactant | 1-[(4-fluorophenyl)sulfonyl]-4-vinyl-1H-indole | HCID 68714238 | — |
| Reactant | 1-[(2-Methoxy-5-methylphenyl)sulfonyl]-1H-indole-4-carbaldehyde | HCID 86618234 | — |
| Catalyst | Osmium Tetroxide | HCID 30318 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-[(4-Fluorophenyl)sulfonyl]-1H-indole-4-carbaldehyde | HCID 86618236 | — |
Reaction Steps
The procedure for Intermediate 8 was followed using OsO4 (15 mg, 0.058 mmol), 1-[(4-fluorophenyl)sulfonyl]-4-vinyl-1H-indole (347 mg, 1.15 mmol; Intermediate 12), 2,6-lutidine (268 μL, 2.3 mmol), dioxane (15 mL), sodium periodate (0.984 g, 4.6 mmol) and water (5 mL). The title compound (360 mg, 103%, still some dioxane according to HNMR) was obtained as a black sticky oil. MS (ESI+) for C15H10FNO3S m/z 304 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812017B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-610c575ba4c0477aa2848083eb323d8b |
| Source note | uspto-grants-2010_10 |