Tributylvinyltin → HCID 68713053, compound

Participants

Reaction Steps

4-Bromo-1-[(2-methylphenyl)sulfonyl]-1H-indole (500 mg, 1.43 mmol; Intermediate 14) was dissolved in dry MeCN (8 mL) and distributed into two microwave vials. Tributyl(vinyl)stannane (0.417 mL, 1.43 mmol) and Pd(PPh3)2OAc2 (27 mg, 0.036 mmol) was added to each vial. The reaction mixtures were irradiated with microwaves at 180° C. for 720 s. The mixtures were combined, filtered and concentrated. Purification was performed by flash chromatography (30% hexane in DCM). This afforded the product (300 mg, 71%) as a yellow sticky oil. MS (ESI+) for C17H15NO2S m/z 298 (M+H)+.

Provenance & Evidence