反应详情

4-Bromo-7-methoxy-1-(phenylsulfonyl)-1H-indole (200 mg, 0.55 mmol, Intermediate 43), tributylvinyltin (348 mg, 1.1 mmol) and bis(acetate)bis(triphenylphosphine)-palladium(II) (46 mg, 0.06 mmol) were mixed in dry acetonitrile (2 mL) and heated in microwave at 180 deg for 10 min. The reaction mixture was filtered through celite and concentrated. The crude product was purified by column chromatography on silica (CHCl3/hexane 7:3) to give 4-vinyl-7-methoxy-1-(phenylsulfonyl)-1H-indole, 0.19 g, which was used immediately in the next step.

1. temperatureheated in microwave at 180 deg for 10 min
2. filtrationThe reaction mixture was filtered through celite
3. concentrationconcentrated
4. customThe crude product was purified by column chromatography on silica (CHCl3/hexane 7:3)