Water → HCID 68715097, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 4-{[4-(tert-butoxycarbonyl)piperazin-1-yl]methyl}-5-methoxy-1-(phenylsulfonyl)-1H-indole-2-carboxylate (330 mg, 0.6 mmol, Intermediate 56) was dissolved in THF (10 mL) before lithium hydroxide (17 mg, 0.7 mmol) was added followed by 4 mL water. The reaction mixture was heated to 70° C. for 24 h before the reaction was completed. The reaction mixture was evaporated. This gave 3 g of a white solid which was washed with several portions of hot DCM and then hot THF. The combined wash phases were evaporated. This gave 270 mg of a slightly brown solid. Yield 83%. MS (ESI+) for C26H30N3O7SLi m/z 530 (M+H)+.

Provenance & Evidence