Trifluoroacetic acid methylene chloride → HCID 68716636, compound

Participants

Reaction Steps

tert-Butyl 4-{[5-hydroxy-1-(phenylsulfonyl)-1H-indol-4-yl]methyl}piperazine-1-carboxylate, (10 mg, 0.018 mmol, Intermediate 64) was dissolved in DCM/TFA 50/50 (1 mL) and left in RT for 4 hours after which time the solvent was removed at reduced pressure and the residue was purified on a preparative HPLC, Method A, to yield 5.5 mg (53%) of the target compound as a colourless oil. MS (ESI+) for C19H21N3O3S m/z 372 (M+H)+.

Provenance & Evidence