Piperazine → HCID 68716587, compound

Participants

Reaction Steps

1-Benzenesulfonyl-7-methoxy-1H-indole-4-carbaldehyde (50 mg, 0.2 mmol, prepared as in Example 79), piperazine (28 mg, 0.3 mmol) and methanol (0.5 mL) was charged into a tube suitable for microwave irradiation. The mixture was heated at 100° for 1 min in the microwave oven. Trimethylsilyl cyanide (21 μl, 0.2 mmol) was added and the heat treatment, 100° 1 min, was repeated. LCMS indicated the formation of expected product. The crude product was purified using prep LC on a YMC column (24-52% MeCN over 16 min). Obtained 26.2 mg (40%). MS ESI+ for C16H13NO4S, m/z 325 (M-piperazine)+, m/z 384 (M-nitrile)+, m/z 411 (M+H)+.

Provenance & Evidence