Sodium Acetate → HCID 68712147, compound

Participants

Reaction Steps

1-Benzenesulfonyl-7-methoxy-1H-indole-4-carbaldehyde (20 mg, 0.06 mmol prepared as in Example 79) azetidine hydrochloride (30 mg, 0.32 mmol) and sodium acetate (26 mg, 0.32 mmol) were mixed in 1,2-dichloroethane (1 mL), and stirred at 40° for 1 h, cooled to room temp followed by addition of sodium triacetoxyborohydride (22 mg, 0.1 mmol). The mixture was stirred over night. No remaining starting material according to LCMS. The mixture was evaporated, dissolved in DMF, filtered an purified on prep HPLC YMC 40 mL/min 22-50 mL MeCN over 16 min. Obtained 9.8 mg (43%). MS ESI+ for C19H20N2O3S m/z 357 (M+H)+.

Provenance & Evidence