Trifluoroacetic acid methylene chloride → 5-(Benzyloxy)-1-(phenylsulfonyl)-4-(piperazin-1-ylmethyl)-1H-indole

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Reaction Steps

tert-Butyl 4-{[5-(benzyloxy)-1-(phenylsulfonyl)-1H-indol-4-yl]methyl}piperazine-1-carboxylate (30 mg, 0.05 mmol, Intermediate 63) was stirred with a 50/50 mixture of TFA/dichlorometane (3 mL) in room temperature for four hours. The solvent was removed at reduced pressure and the crude was purified on a preparative HPLC, method B, to give 9.5 mg (40%) of a colorless oil. MS (ESI+) for C26H27N3O3S m/z 462 (M+H)+.

Provenance & Evidence