Hydrochloric Acid → 1-(Phenylsulfonyl)-1H-indol-5-ol

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(benzyloxy)-1-(phenylsulfonyl)-1H-indole (0.50 g, 1.37 mmol; Intermediate 86) in EtOH (3 mL), Pd/C (30 wt %, 0.15 g), cyclohexene (1 mL), and HCl (1 mL) and was added. The reaction mixture was warmed to 150° C. for 1 h using microwave heating. The Pd/C was filtered off and the solvent was removed under reduced pressure. The product (about 95% pure) was used without further purification.

Provenance & Evidence