Water → HCID 68717072, compound

Participants

Reaction Steps

NaH (95%) (101 mg, 4.23 mmol), was added to a solution of 4-[(dimethylamino)methyl]-1-(phenylsulfonyl)-1H-indol-5-ol (700 mg, 2.11 mmol; Example 131) in DMF (20 ml) at ambient temperature. The mixture was stirred for 15 min before iodoethane (0.203 ml, 2.54 mmol) was added. After 1 h water was added and the mixture extracted with Et2O. A small portion was purified on Gilson HPLC using 20-50% MeCN in 0.1% TFA. Yield: 65 mg; colorless oil. MS (ESI+) for C19H22N2O3S m/z 359 (M+H)+.

Provenance & Evidence