Ethanol → HCID 68717165, compound

Participants

Reaction Steps

{[5-Ethoxy-1-(phenylsulfonyl)-1H-indol-4-yl]methyl}dimethylamine (655 mg, 1.831 mmol; Example 133) was added EtOH (5 ml) and 2 M NaOH (5 ml) and heated at 70 oC for 5 h. Water was added and white material precipitated. The mixture was extracted with DCM. The organic phase was extracted with 1 M HCl (3×20 ml). The aqueous phase was made alkaline (pH 9) using 2 M NaOH and extracted with DCM (3×50 ml). The combined organic layers were dried (MgSO4) and evaporated. Yield: 293 mg (74%); brown oil. MS (ESI+) for C13H18N2O m/z 219 (M+H)+.

Provenance & Evidence