Formaldehyde → HCID 59513604, compound

Participants

Reaction Steps

Paraformaldehyde (20.6 mg, 0.686 mmol) and N-ethylmethylamine (0.059 ml, 0.686 mmol) in EtOH (1 ml) was heated until a clear solution was obtained. The solution was added to 6-fluoro-1-(phenylsulfonyl)-1H-indol-5-ol (100 mg, 0.343 mmol; Intermediate 95) in EtOH (1 ml) and the mixture was heated in microwave oven at 90 oC for 10 min. Solvent was evaporated and 20% of material was purified on Gilson HPLC using 15-45% MeCN in 50 nM ammonium hydrogencarbonate buffer. Yield: 13 mg; white solid. MS (ESI+) for C18H19FN2O3S m/z 363 (M+H)+.

Provenance & Evidence