Methylamine → HCID 59513542, compound

Participants

Reaction Steps

A solution of 4-(1-iodoethyl)-1-(phenylsulfonyl)-1H-indole (50 mg, 122 μmol; Intermediate 99) in CH2Cl2 (1.5 mL) was treated with MeNH2 (153 μL of a 8 M solution in EtOH, 1.22 mmol) at rt for 2 h. The reaction mixture was concentrated in vacuo, the obtained residue taken up with MeOH/THF and purified by prep. HPLC (System B, 22-52% MeCN, 50 mM NH4HCO3) to yield the title compound as a white, waxy solid (13.2 mg, 12% over two steps). MS (ESI+) for C17H18N2O2S m/z 284 (M-NHMe)+, 315 (M+H)+.

Provenance & Evidence