Dimethylamine → HCID 59513570, compound

Participants

Reaction Steps

A solution of crude 6-fluoro-4-(1-iodoethyl)-1-(phenylsulfonyl)-1H-indol-5-ol (ca. 44.5 μmol; Intermediate 104) in CH2Cl2 (1 mL) was treated with Me2NH (159 μL of a 5.6 M solution in EtOH, 890 μmol) at rt for 1.5 h. The reaction mixture was concentrated in vacuo, the obtained residue taken up with MeOH and purified by prep. HPLC (25-55% MeCN, 50 mM NH4HCO3) to yield the title compound as an off-white solid (10.0 mg, 62% over two steps). MS (ESI+) for C18H19FN2O3S m/z 363 (M+H)+.

Provenance & Evidence