Methyl iodide → HCID 86618265, compound

Participants

Reaction Conditions

Reaction Steps

Crude 6-fluoro-5-hydroxy-1-(phenylsulfonyl)-1H-indole-4-carbaldehyde (85 mg, 266 μmol; Intermediate 96) was suspended in acetone (5 mL) and treated with K2CO3 (73.6 mg, 532 μmol) and MeI (49.7 μL, 798 μmol) and stirred in a sealed tube at 65° C. for 1 h 30 min. The reaction mixture was cooled to rt and diluted with CH2Cl2, washed with H2O, dried (Na2SO4) and the solvent removed in vacuo to give 6-fluoro-5-methoxy-1-(phenylsulfonyl)-1H-indole-4-carbaldehyde as an intense yellow, vitreous solid (72.3 mg), 65% pure according to LC/MS, which was directly used in the subsequent Grignard addition.

Provenance & Evidence