HCID 28721148, compound → HCID 59513862, compound

HRID 1159893Notes

Reaction equation

HRID 1159893 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:9]([C:17]3[CH:18]=[C:19]([NH:23][C:24](=[O:33])[C:25]4[C:30]([F:31])=[CH:29][CH:28]=[CH:27][C:26]=4[F:32])[CH:20]=[CH:21][CH:22]=3)=[N:10][N:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=23)[CH:5]=[CH:4][N:3]=1.[N:34]1([CH2:40][CH2:41][CH2:42][C:43]2[CH:44]=[C:45]([NH2:49])[CH:46]=[CH:47][CH:48]=2)[CH2:39][CH2:38][O:37][CH2:36][CH2:35]1>>[F:32][C:26]1[CH:27]=[CH:28][CH:29]=[C:30]([F:31])[C:25]=1[C:24]([NH:23][C:19]1[CH:20]=[CH:21][CH:22]=[C:17]([C:9]2[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([NH:49][C:45]4[CH:46]=[CH:47][CH:48]=[C:43]([CH2:42][CH2:41][CH2:40][N:34]5[CH2:35][CH2:36][O:37][CH2:38][CH2:39]5)[CH:44]=4)[N:7]=3)=[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][N:11]3[N:10]=2)[CH:18]=1)=[O:33]

Participants

3

Reactant 2

HCID 28721148HCID 28721148, compoundHCID 59513803N-{3-[3-(2-Chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide

Product 1

HCID 59513862HCID 59513862, compound

Procedure

N-{3-[3-(2-Chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide and {3-[3-(4-morpholinyl)propyl]phenyl}amine were reacted in a manner analogous to Example 27, Step D, to give the title compound. MS (ESI): M+H=646.27.

Sources & evidence

ORD record
ord-b0c4ac0cd3fa418199470f001942594d
Source dataset
uspto-grants-2010_10
Patent number
US07812022B2

Reaction notes

Loading…