HRID1159901

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID88969

Benzoyl chloride, 2-methoxy-

C8H7ClO2

结构：Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3cccc(F)c3)n2)c1

HCID59511403

未命名化合物

结构：O=C(Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc4c(c3)CNCC4)n2)c1)c1ccccc1

HCID59513880

未命名化合物

PRODUCTS

生成物

结构：COc1ccccc1C(=O)Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3cccc(F)c3)n2)c1

HCID59513869

未命名化合物

PROCEDURE

实验过程

In a manner analogous to Example 66, the title compound may be obtained by reacting 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(3-fluorophenyl)-2-pyrimidinamine and 2-methoxybenzoyl chloride. HRMS: calc. C28H20N6OFS calcd for C31H23FN6O2: 530.1867, found: 531.1941 (M+H)+ 507.1403 found 507.1427+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d45021e038d8439fac9324ccb590cf2e
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07812022B2
来源说明: uspto-grants-2010_10

反应 SMILES

C1C2C(=CC=C(NC3N=C(C4C(C5C=C(NC(=O)C6C=CC=CC=6)C=CC=5)=NN5C=CC=CC=45)C=CN=3)C=2)CCN1.[NH2:42][C:43]1[CH:44]=[C:45]([C:49]2[C:57]([C:58]3[CH:63]=[CH:62][N:61]=[C:60]([NH:64][C:65]4[CH:70]=[CH:69][CH:68]=[C:67]([F:71])[CH:66]=4)[N:59]=3)=[C:52]3[CH:53]=[CH:54][CH:55]=[CH:56][N:51]3[N:50]=2)[CH:46]=[CH:47][CH:48]=1.[CH3:72][O:73][C:74]1[CH:82]=[CH:81][CH:80]=[CH:79][C:75]=1[C:76](Cl)=[O:77]>>[F:71][C:67]1[CH:66]=[C:65]([NH:64][C:60]2[N:59]=[C:58]([C:57]3[C:49]([C:45]4[CH:44]=[C:43]([NH:42][C:76](=[O:77])[C:75]5[CH:79]=[CH:80][CH:81]=[CH:82][C:74]=5[O:73][CH3:72])[CH:48]=[CH:47][CH:46]=4)=[N:50][N:51]4[CH:56]=[CH:55][CH:54]=[CH:53][C:52]=34)[CH:63]=[CH:62][N:61]=2)[CH:70]=[CH:69][CH:68]=1