HRID1159902

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3cccc(F)c3)n2)c1

HCID59511403

未命名化合物

反应SMILES：O=C(Cc1c(C(=O)Cl)ccc(F)c1Br)c1cccs1

HCID86618778

未命名化合物

PRODUCTS

产物

反应SMILES：O=C(Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc4c(c3)CNCC4)n2)c1)c1ccccc1

HCID59513880

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in a manner analogous to Example 66, using 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(3-fluorophenyl)-2-pyrimidinamine and 3-bromofluoro-2-thiophenecarbonylmethylbenzoyl chloride. HRMS: calc. C28H19N6OSFBr calcd for C31H22F2N6O: 532.1823, found: 533.1921 (M+H)+ 585.0508 found 585.0515+).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-6d45f1dd7de949e6bc9f02f964fde9c7
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07812022B2
来源说明: uspto-grants-2010_10

反应SMILES

[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]([C:17]3[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C:24]4[CH:29]=[CH:28][CH:27]=[C:26](F)[CH:25]=4)[N:18]=3)=[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][N:10]3[N:9]=2)[CH:5]=[CH:6][CH:7]=1.Br[C:32]1[C:33](CC(C2SC=CC=2)=O)=[C:34]([CH:38]=[CH:39][C:40]=1F)[C:35](Cl)=[O:36]>>[CH2:15]1[C:26]2[C:27](=[CH:28][CH:29]=[C:24]([NH:23][C:19]3[N:18]=[C:17]([C:16]4[C:8]([C:4]5[CH:3]=[C:2]([NH:1][C:35](=[O:36])[C:34]6[CH:33]=[CH:32][CH:40]=[CH:39][CH:38]=6)[CH:7]=[CH:6][CH:5]=5)=[N:9][N:10]5[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=45)[CH:22]=[CH:21][N:20]=3)[CH:25]=2)[CH2:12][CH2:11][NH:10]1