5-Fluoro-2-methylbenzoyl chloride → N-(3-{3-[2-(1,2,3,4-tetrahydro-7-isoquinolinylamino)-4-pyrimidinyl]-pyrazolo[1,5-a]pyridin-2-yl}phenyl)benzamide

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Reaction Steps

The title compound was prepared from 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(3-fluorophenyl)-2-pyrimidinamine and 5-fluoro-2-methylbenzoyl chloride in a manner analogous to Example 66. 1H NMR (300 MHz, DMSO-d6): δ 10.48 (s, 1H), 9.80 (s, 1H), 8.85 (d, 1H), 8.47 (d, 1H), 8.32 (d, 1H), 8.07 (s, 1H), 7.84 (d, 1H), 7.77 (m, 1H), 7.53-7.42 (m, 3H), 7.36-7.28 (m, 3H), 7.26-7.18 (m, 2H), 7.13 (m, 1H), 6.71 (m, 1H), 6.60 (d, 1H), 2.32 (s, 3H); HRMS: calc. C31H23N6OF2 (M+H)+ 533.1901 found 533.1904.

Provenance & Evidence