4-(4-Methylpiperazin-1-yl)aniline → N-(3-{3-[2-(1,2,3,4-tetrahydro-7-isoquinolinylamino)-4-pyrimidinyl]-pyrazolo[1,5-a]pyridin-2-yl}phenyl)benzamide

Participants

Reaction Steps

The title compound was prepared from N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide and 4-(4-methyl-1-piperazinyl)aniline by a procedure similar to Example 27, Step D. 1H NMR (400 MHz, DMSO-d6) δ 2.26 (s, 3H), 2.48-2.54 (m, 4H overlapping with d6-DMSO), 3.02-3.10 (m, 4H), 6.52 (d, 1H, J=5.2 Hz), 6.88 (d, 2H, J=8.8 Hz), 7.15 (t, 1H, J=6.0 Hz), 7.29 (t, 2H, J=8.0 Hz), 7.37 (d, 1H, J=7.8 Hz), 7.46-7.66 (m, 5H), 7.85 (d, 1H, J=8.7 Hz), 8.04 (s, 1H), 8.25 (d, 1H, J=5.2 Hz), 8.45 (bd, 1H, J=8.9 Hz), 8.97 (d, 1H, J=6.9 Hz), 9.31 (s, 1H), 10.98 (s, 1H); ESIMS (M+H)+=617.

Provenance & Evidence