1,4-Benzodioxan-6-ylamine → N-(3-{3-[2-(1,2,3,4-tetrahydro-7-isoquinolinylamino)-4-pyrimidinyl]-pyrazolo[1,5-a]pyridin-2-yl}phenyl)benzamide

Participants

Reaction Steps

The title compound was prepared from N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide and 2,3-dihydro-1,4-benzodioxin-6-amine in a manner analogous to Example 64. 1H NMR (400 MHz, DMSO-d6) δ 4.20 (m, 4H), 6.45 (d, 1H, J=5.3 HZ), 6.72 (d, 1H, J=8.8 Hz), 7.10 (m, 2H), 7.22 (m, 2H), 7.28 (m, 2H), 7.35 (m, 2H), 7.46 (d, 1H, J=8.1 Hz), 7.98 (s, 1H), 8.20 (d, 1H, J=5.3 Hz), 8.83 (d, 1H, J=6.9 Hz), 9.35 (s, 1H), 10.93 (s, 1H); ESIMS (M+H)+=577.

Provenance & Evidence