Benzenesulfonamide, 3-amino- → N-(3-{3-[2-(1,2,3,4-tetrahydro-7-isoquinolinylamino)-4-pyrimidinyl]-pyrazolo[1,5-a]pyridin-2-yl}phenyl)benzamide

Participants

Reaction Steps

The title compound was prepared by a procedure similar to Example 27, Step D using N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide and 3-aminobenzenesulfonamide: 1H NMR (400 MHz, DMSO-d6): δ 10.92 (s, 1H); 9.87 (s, 1H); 8.84 (d, 1H); 8.53 (d, 1H); 7.92 (d, 1H); 7.81 (d, 1H); 7.57 (m, 1H); 7.47 (m, 1H); 7.38 (m, 2H); 7.25 (m, 3H); 7.12 (m, 3H); 6.98 (s, 1H); 6.90 (d, 1H); 6.68 (d, 1H); 6.57 (d, 1H); 5.48 (br s, 1H). HRMS (ESI): (M+H)+ calculated 598.1473, found 598.1467.

Provenance & Evidence