HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 11643172, compound → 4-[3-(Dimethylamino)propoxy]-3-fluoroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 11643172 | HCID 11643172 | — |
| Reactant | 3-(2-Fluoro-4-nitrophenoxy)-N,N-dimethyl-1-propanamine | HCID 59513823 | — |
| Product | 4-[3-(Dimethylamino)propoxy]-3-fluoroaniline | HCID 26190135 | — |
Reaction Steps
In an analogous procedure to Example 125, 343 mg of the title compound was prepared from {3-[(2-fluoro-4-nitrophenyl)oxy]propyl}dimethylamine to give the desired intermediate as brown oil: 1H NMR (CDCl3, 400 MHz) δ 1.89-1.96 (m, 2H), 2.24 (s, 6H), 2.44 (t, 2H, J=7.1 Hz), 3.49 (brs, 2H), 3.99 (t, 2H, J=6.5 Hz), 6.36 (d, 1H, J=8.6 Hz), 6.45 (dd, 1H, J=12.6 and 2.7 Hz), and 6.81 (dd, 1H, J=9.0 and 9.0 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812022B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-dd870de470c34c8aa2fb22754a88e93c |
| Source note | uspto-grants-2010_10 |