Pyrrolidine → HCID 59511429, compound

Participants

Reaction Conditions

Reaction Steps

N-(3-{3-[2-({3-[(2-Chloroethyl)oxy]phenyl}amino)-4-pyrimidinyl]pyrazolo[1,5-a]pyridin-2-yl}phenyl)-2,2,2-trifluoroacetamide (0.500 g, 0.850 mmol) was dissolved in pyrrolidine and heated to 50° C. for 18 h. The reaction was cooled upon completion and absorbed directly onto silica gel. The crude product was purified via column chromatography using a 0-20% gradient of EtOAC/MeOH w/NH4OH to afford the desired product (310 mg, 74% yield) as a yellow solid. ES-LCMS m/z 492 (M+H).

Provenance & Evidence