HCID 18382547, compound → N-[3-(3-{2-[(2-Amino-2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide

HRID 1159982Notes

Reaction equation

HRID 1159982 reaction equation
C[N:2]1[CH2:11][C:10](C)(C)[C:9]2[C:4](=[CH:5][C:6]([NH2:14])=[CH:7][CH:8]=2)[CH2:3]1.Cl[C:16]1[N:21]=[C:20]([C:22]2[C:23]([C:31]3[CH:32]=[C:33]([NH:37][C:38](=[O:47])[C:39]4[C:44]([F:45])=[CH:43][CH:42]=[CH:41][C:40]=4[F:46])[CH:34]=[CH:35][CH:36]=3)=[N:24][N:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=23)[CH:19]=[CH:18][N:17]=1>>[NH2:2][CH:11]1[CH2:3][C:4]2[C:9](=[CH:8][CH:7]=[C:6]([NH:14][C:16]3[N:21]=[C:20]([C:22]4[C:23]([C:31]5[CH:32]=[C:33]([NH:37][C:38](=[O:47])[C:39]6[C:40]([F:46])=[CH:41][CH:42]=[CH:43][C:44]=6[F:45])[CH:34]=[CH:35][CH:36]=5)=[N:24][N:25]5[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=45)[CH:19]=[CH:18][N:17]=3)[CH:5]=2)[CH2:10]1

Participants

3

Reactant 2

HCID 18382547HCID 18382547, compoundHCID 59513803N-{3-[3-(2-Chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide

Product 1

HCID 59513754N-[3-(3-{2-[(2-Amino-2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide

Procedure

The title compound was prepared following a procedure similar to the Example 177, Step C, from 2,4,4-trimethyl-1,2,3,4-tetrahydro-7-isoquinolinamine (50 mg, 0.26 mmol) (synthesized as described in patent WO 0009486, p. 18) and N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide (101 mg, 0.22 mmol, prepared according to a procedure similar to that described in Example 27, Step C). ESIMS (M+H)+=616.32.

Sources & evidence

ORD record
ord-10d14424e787408c88cce83e18944c00
Source dataset
uspto-grants-2010_10
Patent number
US07812022B2

Reaction notes

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