HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 59513864, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-Benzothiazolamine, 2-methyl- | HCID 36229 | — |
| Reactant | N-{3-[3-(2-Chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide | HCID 59513803 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 59513864 | HCID 59513864 | — |
Reaction Steps
A mixture of N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide (which may be prepared according to a procedure similar to Example 27, Step C) and 2-methyl-1,3-benzothiazol-5-amine are heated in isopropanol with catalytic conc. HCl at approximately 85° C. to afford the product. ES-LCMS m/z 590 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812022B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-887eb8c649074b26acdb0b39a2caa777 |
| Source note | uspto-grants-2010_10 |