Pyridine → HCID 12266212, compound

Participants

Reaction Steps

To a solution of 2-bromo-4′-methyl-acetophenone (784 mg, 3.31 mmol) in acetone (7 mL) was added pyridine (243 μl, 3.02 mmol). The mixture was refluxed for 2 hours and the white solid formed was isolated by filtration and rinsed with Et2O in 100% yield: mp 213-214° C.; 1H NMR 400 MHz (DMSO-d6) δ 2.45 (s, 3H), 6.50 (s, 2H), 7.48 (d, 2H, J=7.3 Hz), 7.97 (d, 2H, J=7.8 Hz), 8.28 (m, 2H), 8.74 (t, 1H, J=7.3 Hz), 9.03 (d, 2H, J=5.9 Hz); Elem. anal. found: C, 55.46; H, 5.40; N, 4.85% (calcd for C14H14BrNO ½H2O: C, 55.83; H, 5.02; N, 4.65%).

Provenance & Evidence