反应详情

2,6-Dichloro-8-azapurine (0.84 mmol), prepared as described in Example 17, was dissolved in n-butanol (4 ml) and benzylamine (1.4 mmol) was added. The reaction mixture was stirred at room temperature overnight. After concentration in vacuo the product was purified by chromatography (SiO2, IV—from 1% MeOH and 0.25% acetic acid to 2% MeOH with 0.35% acetic acid).

1. concentrationAfter concentration in vacuo the product
2. customwas purified by chromatography (SiO2, IV—from 1% MeOH and 0.25% acetic acid to 2% MeOH with 0.35% acetic acid)