Methylamine → HCID 11773466, compound

Participants

Reaction Steps

To a 50 mL round-bottomed flask were added 2-(2-Amino-5-cyano-6-methanesulfinyl-pyrimidin-4-ylsulfanyl)-N-(3-trifluoromethyl-phenyl)-acetamide (0.2 mmol, 1.0 eq.), methyl amine (2M in THF, 0.3 mmol), and acetonitrile (1 mL). The reaction mixture was stirred at room temperature for overnight. The crude material was purified by column chromatography (18 mg). LC-MS: (ES+) m/z 383 (M+1). 1H-NMR, Varian 400 MHz (DMSO-d6) δ 10.47 (s, 1H), 8.07(s, 1H), 7.75 (d, 1H), 7.55 (t, 1H), 7.40 (d, 1H), 7.36 (d, 1H), 7.25 (s, 1H), 3.95 (s, 2H), 2.73 (d, 3H) ppm.

Provenance & Evidence