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HRID1160134

反应详情

EQUATION

反应方程式

HRID 1160134 的结构方程式

REACTANTS

反应物

3
结构：CCO
HCID702

Ethanol

C2H6O

结构：CN1C(C)(C)CC(NC(=O)c2ccc(NN)cc2)CC1(C)C
HCID59515576

未命名化合物

结构：CCOC(=O)CC(=O)c1ccno1
HCID59515581

未命名化合物

PRODUCTS

生成物

1
结构：CN1C(C)(C)CC(NC(=O)c2ccc(-n3[nH]c(-c4ccno4)cc3=O)cc2)CC1(C)C
HCID59515579

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

CONDITIONS

反应条件

温度
65 °C

PROCEDURE

实验过程

3-Isoxazol-5-yl-3-oxo-propionic acid ethyl ester (49 mg) and 4-Hydrazino-N-(1,2, 2,6,6-pentamethyl-piperidin-4-yl)-benzamide (93 mg) were dissolved into ethanol (2.5 ml) and acetic acid (0.3 ml) and the solution stirred at 65° C. for 2 h. Concentration in vacuo and purification by HPLC gave the expected product. LC/MS: main peak is product (m/z: 424.3)

WORKUP

后处理

  1. concentrationConcentration
  2. customin vacuo and purification by HPLC