Ethyl Acetate → HCID 58878196, compound

Participants

Reaction Steps

7-(3-Chlorophenyl)-5-methylsulfanyl-2-[4-(pyridin-4-yloxy)phenylamino]-1,2,4-triazolo[1,5-a]pyrimidine-6-carbonitrile (50 mg, 0.10 mol) is heated at 100° C. for 18 h in 1-methylpiperazine (1 ml) in a closed vessel. Ethyl acetate (5 ml) is added to the cooled solution, and the precipitate which forms is filtered off, washed with diethyl ether and dried, giving 32 mg (0.06 mmol, 55%) of “136”, [M+H]+ 539.

Provenance & Evidence