関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Methylphenylhydrazine monohydrochloride | HCID 12504 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | N,5-Dimethyl-1H-indol-2-amine dihydrochloride | HCID 57435942 | — |
反応手順
5 g of 1-(4-methylphenyl)hydrazine hydrochloride are dissolved in water and then triethylamine is added until the salt has been neutralized. Extraction is carried out with AcOEt and then the extract is evaporated to dryness. The precipitate formed is dissolved in 30 ml of ether and then a solution of 4.6 ml of acetic anhydride dissolved in 30 ml of ether is added dropwise. The mixture is stirred at 0° C. for 15 minutes and then the precipitate formed is filtered off to produce 3 g of the expected compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07816368B2 |
|---|
| 出典データセット | uspto-grants-2010_10 |
|---|
| ORD ID | ord-a5e4eb59d383489fa7bec22d8e009946 |
|---|
| 出典メモ | uspto-grants-2010_10 |
|---|
