HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(Chloromethyl)-5-(trifluoromethyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (5-(trifluoromethyl)pyridin-2-yl)methanol HCl salt | HCID 68694003 | — |
| Product | 2-(Chloromethyl)-5-(trifluoromethyl)pyridine | HCID 18361720 | — |
| Product | 2-(Chloromethyl)-5-(trifluoromethyl)pyridine hydrochloride | HCID 68691446 | — |
Reaction Steps
The mixture of (5-(trifluoromethyl)pyridin-2-yl)methanol HCl salt (293 mg, 1.4 mmol) and SOCl2 (1.5 ml) was stirred for 10 min. After this time, the solution was concentrated under reduced pressure to give the title compound, 2-(chloromethyl)-5-(trifluoromethyl)pyridine HCl salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816357B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-35205fb3e7a441dd9cf647040934d051 |
| Source note | uspto-grants-2010_10 |