Ethyl chloroformate → HCID 86761195, compound

Participants

Reaction Steps

Compound ST3576 was obtained (0.931 mg, 98% yield) after acid hydrolysis of (2E)-3-{3-[(2-Morpholin-4-yl-ethoxyimino)-methyl]-phenyl}-N-trityloxy-acrylamide obtained (1.500 g, 2.67 mmol, 65% yield) by reaction of intermediate C (1.400 g, 4.12 mmol) with ethyl chloroformate (472 μL, 4.94 mmol) and TEA (746 μL, 5.35 mmol) in 5 mL of anhydrous THF (according to procedure described in Mai A., Pezzi R. et all. J. Med. Chem. 2005, 48, 3344 and in Mai A., Pezzi R. et all. J. Med. Chem. 2003, 46, 4826).

Provenance & Evidence