Thionyl Chloride → HCID 86622504, compound

Participants

Reaction Steps

Compound (2E)-3-{4-[(4-Nitro-benzyloxyimino)-methyl]-phenyl}-N-tritylsulfanyl-acrylamide was obtained (0.050 g, 0.08 mmol, 26% yield) by reaction of intermediate C (2E)-3-[4-({[(4-nitrobenzyl)oxy]imino}-methyl)phenyl]acrylic acid (ST3075, 0.100 g, 0.31 mmol) with SOCl2 (34 μL, 0.46 mmol), DIEA (236 μL, 1.38 mmol) and Triphenylmethanesulfenamide (0.098 g, 0.14 mmol) in anhydrous DCM at room temperature.

Provenance & Evidence