Potassium Carbonate → HCID 178497513, compound

Participants

Reaction Conditions

Reaction Steps

Mix Trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-2-oxo-trans-1-(4-triisopropylsilanyloxy-cyclohexyl)-pyrrolidin-3-ylmethyl]-phenyl ester (Preparation 19) (1.70 g, 2.64 mmol), (4-methoxycarbonylphenyl)boronic acid (0.576 g, 3.17 mmol), tetrakis(triphenylphosphine)palladium(0) (0.305 g, 0.26 mmol) and 1.32 ml of 2M solution of K2CO3 in DME (10 mL). Stir for 12 hours at 80° C. Quench the reaction with water and extract with ethyl acetate. Wash the extract with brine and dry over magnesium sulfate. Flash chromatography affords 1.32 g (80%) of the title compound: Mass spectrum (apci) m/z=632 (M+H).

Provenance & Evidence