HCID 178497513, compound → HCID 178460988, compound

Participants

Reaction Steps

Place 3′,5′-Dichloro-4′-[(R)-2-oxo-trans-1-(4-triisopropylsilanyloxy-cyclohexyl)-pyrrolidin-3-ylmethyl]-biphenyl-4-carboxylic acid methyl ester (Preparation 20) (1.32 g, 2.09 mmol) in MeOH (10 mL) and 1N NaOH solution (10 mL). Stir for 3 hours at reflux. Strip most of the solvent and quench with 1N HCl. Filter white precipitate and rinse with water on the filter. After drying receive 0.95 g (74%) of the title compound: Mass spectrum (apci) m/z=617 (M+H).

Provenance & Evidence