Tetrabutylammonium Fluoride → HCID 178519417, compound

Participants

Reaction Steps

Mix (R)-3-[3,5-Dichloro-4′-(4-trifluoromethyl-piperidine-1-carbonyl)-biphenyl-4-ylmethyl]-trans-1-(4-triisopropylsilanyloxy-cyclohexyl)-pyrrolidin-2-one (Preparation 22) (0.548 g, 0.78 mmol) and TBAF (1.55 ml, 1.55 mmol) in 15 ml of dry THF. Stir at room temperature for 2 hours. Quench with saturated NaHCO3 extract with ethyl acetate. Wash with brine. Dry over magnesium sulfate, filter, and concentrate. After flash column chromatography receive 0.448 g (97%) of the title compound: Mass spectrum (apci) m/z=596 (M+H).

Provenance & Evidence