Methyl o-toluate → Methyl 2-(bromomethyl)benzoate

HRID 1160377Notes

Reaction equation

HRID 1160377 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[Br:12]N1C(=O)CCC1=O>C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.C(Cl)(Cl)(Cl)Cl>[Br:12][CH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

Participants

5

Reactant 2

HCID 33094Methyl o-toluateHCID 67184N-bromobutanimide

Product 1

HCID 2734813Methyl 2-(bromomethyl)benzoateYield 98%

Reagents, catalysts & solvents 2

HCID 7187Benzoyl PeroxideCatalystHCID 5943Carbon TetrachlorideSolvent

Procedure

50 g of methyl 2-methylbenzoate (0.33 M), 60.4 g of N-bromosuccinimide (0.340 M) and 4 g of benzoyl peroxide are added to a 2000 ml reactor containing 1500 ml of carbon tetrachloride. The reaction mixture is refluxed for 2 hours. After cooling to room temperature, the reaction medium is concentrated under vacuum. The oil obtained is purified by chromatography on silica (eluent: CH2Cl2). 74.5 g of a colourless oil are obtained (98% yield).

Workup

  1. temperatureThe reaction mixture is refluxed for 2 hours
  2. concentrationthe reaction medium is concentrated under vacuum
  3. customThe oil obtained
  4. customis purified by chromatography on silica (eluent: CH2Cl2)

Sources & evidence

ORD record
ord-5586507bfd784e549776bfb0a5ca1e27
Source dataset
uspto-grants-2010_10
Patent number
US07816397B2

Reaction notes

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