HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1160409Generated: October 30, 2026
1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-(ethylamino)butanoate → Methyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-(ethylamino)butanoate, hydrochloride
https://huagongshe.com/reaction/1160409
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-(ethylamino)butanoate | HCID 59516237 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Product | Methyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-(ethylamino)butanoate, hydrochloride | HCID 131728380 | — |
Reaction Steps
The 1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-(ethylamino)butanoate from the previous step was dissolved in a mixture of MeOH (150 mL) and 4N HCl/dioxane (20 mL) and heated to 60° C. for 3 h. The solvents were concentrated to a slurry, Et2O (200 mL) was added, the solid filtered, washed well with Et2O to give the titled compound (4.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07816395B2 |
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| Source dataset | uspto-grants-2010_10 |
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| ORD ID | ord-ea6e3809411e4da881332af4080c6ea7 |
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| Source note | uspto-grants-2010_10 |
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