Sodium borohydride → HCID 59516003, compound

Participants

Reaction Steps

3,3′-Bistrifluoromethylbiphenyl-4,4′-diacrylic acid dimethyl ester (12.3 9, 26.8 mmol; prepared the same manner as 2,2′-isomer, intermediate 5, step A-B) was dissolved in 200 ml polyethylene glycol (PEG 400) and sodium borohydride (7.4 g, 196 mmol) was added gradually during 30 min at 130° C. The mixture was heated at this temperature for 6 h, after cooling water was added and the mixture was extracted with chloroform. Chloroform extract was dried (MgSO4) and evaporated to give a residue which was submitted to chromatography on silica gel. Elution with ethyl acetate afforded 1.85 g of the title compound as white crystals.

Provenance & Evidence